| Phase | Study title | N | Study Design | Clinical trial number | EudraCT link |
|---|---|---|---|---|---|
| I | Systemic nitrates in refractory normal tension glaucoma | 100 | EMA CTIS-code 2024-518701-17-00 | ||
| IV | Predictability of response of aflibercept treatment for wet age-related macular degeneration under the treat-and-moderate extend regimen (TMER) treatment model | 50 | 00170 | https://www.clinicaltrialsregister.eu/ctr-search/trial/2015-001394-41/FI | |
| IV | Treat-and-extend regimen (TER) in patients with diabetic macular edema | 420 | 00171 | https://www.clinicaltrialsregister.eu/ctr-search/trial/2015-003162-82/FI | |
| IV | Efficacy of steroid and nonsteroidal anti-inflammatory eye drops in management of post-operative inflammation and prevention of pseudophakic cystic macular edema after uncomplicated cataract surgery | 240 | Prospective Randomized Double-blind | 00172 | https://www.clinicaltrialsregister.eu/ctr-search/trial/2015-003296-30/FI |
| IV | Pre and post-operative corticosteroid and NSAID combination treatment in cataract surgery of diabetic patient | 104 | Prospective Randomized Open-Label | 00173 | https://www.clinicaltrialsregister.eu/ctr-search/trial/2016-004514-10/FI |
| I | Cataract surgery without post-operative medication | 100 | Prospective Randomized Open-Label | 00174 | https://www.clinicaltrialsregister.eu/ctr-search/trial/2016-004515-12/FI |
| IV | Non-steroidal anti-inflammatory medication in cataract surgery | 100 | Prospective Randomized Double-Blind | 00175 | https://www.clinicaltrialsregister.eu/ctr-search/trial/2015-005313-79/FI |
| IV | Anti-inflammatory medication in cataract surgery of pseudoexfoliation eyes | 150 | Prospective Randomized Double-Blind | 00176 | https://www.clinicaltrialsregister.eu/ctr-search/trial/2016-004784-40/FI |
Privacy policies (General Data Protection Regulation; GDPR) for clinical studies (since 25th May 2018)
Efficacy of farisimab in wet age-related macular degeneration
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective registry study evaluating the effects of switching from another anti-VEGF therapy to farisimab in wet age-related macular degeneration. The study aims to expand the understanding of the treatment efficacy and response to farisimab to develop better treatment practices in the treatment of wet age-related macular degeneration. The research organization is the University of Helsinki.
Mehiläinen Eye Hospital Ympyrätalo is participating in a retrospective registry study by the Helsinki Retina Research Group, which evaluates the effects of switching from another anti-VEGF treatment to farisimab in wet age-related macular degeneration. The study aims to expand the understanding of the treatment efficacy and response to farisimab to develop better treatment practices in the treatment of wet age-related macular degeneration. The research organization is the University of Helsinki, and the data authority is Findata, which implements the authorization and anonymizes the data for the use of the research group.
The impact of the choice of intraocular lens in cataract surgery on the incidence and progression of glaucoma
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective registry study, which evaluates the impact of intraocular lens selection on the incidence and progression of glaucoma. The study aims to expand the understanding of the effects of blue-light filtering on the function of the optic nerve in patients who have undergone cataract surgery. The research organization is the University of Helsinki.
The impact of intraocular lens selection in cataract surgery on the incidence and progression of geographic atrophy
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective registry study, which evaluates the impact of intraocular lens choice on the incidence and progression of geographic atrophy. The study aims to expand the understanding of the effects of blue-light filtering on advanced dry age-related macular degeneration in patients who have undergone cataract surgery. The research organization is the University of Helsinki
The impact of the choice of intraocular lens for cataract surgery on the incidence and progression of associated eye diseases and on general health
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective registry study, which evaluates the impact of cataract surgery and the choice of intraocular lens on e.g., circadian rhythm, dementia, migraine, fractures and other accidents. The study aims to expand the understanding of the effects of blue-light filtering on the incidence of comorbidities and on general health in patients who have undergone cataract surgery.The research organization is the University of Helsinki.
The effect of diabetes, intravitreal steroid, and NSAID drops on the recovery of a patient undergoing ERM surgery
The Helsinki University Hospital Department of Ophthalmology is participating in a retrospective registry study by the Helsinki Retina Research Group, which evaluates the effect of diabetes, intravitreal steroid, and NSAID drops on the recovery of patients undergoing ERM surgery. The study aims to optimize drug treatment for ERM surgery patients.The research organization is the University of Helsinki.
The impact of glycemic control on the long-term prognosis of patients with central retinal vein occlusion
The Helsinki University Hospital Department of Ophthalmology is participating in a retrospective registry study by the Helsinki Retina Research Group, which evaluates the impact of glycemic control on the recovery and long-term prognosis of patients with central retinal vein occlusion (CRVO) in terms of anti-VEGF treatment response, associated complications of CRVO, and best-corrected visual acuity. The study aims to optimize the treatment of patients with CRVO. The research organization is the University of Helsinki.
The effect of aqueous flare levels in cataract surgery long-term outcomes
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective registry study, which evaluates the impact of aqueous flare levels on pseudophakic cystoid macular edema and posterior capsular opacification. The study aims to expand the understanding of the effects of prolonged intraocular inflammation on cataract surgery long-term adverse events. The research organization is the University of Helsinki.
The effect of anti-inflammatory medication on posterior capsular opacification
Helsinki University Hospital Department of Ophthalmology is participating in a retrospective registry study by the Helsinki Retina Research Group, which evaluates the impact of anti-inflammatory medication (steroids, NSAIDs, combination of both) on the cumulative incidence of posterior capsular opacification. The study aims to optimize the postoperative treatment of cataract surgery patients. The research organization is the University of Helsinki.
The effect of intraocular lens dioptric power on posterior capsular opacification
Helsinki University Hospital Department of Ophthalmology and Kymenlaakso Central Hospital Eye Centre are participating in a retrospective registry study by the Helsinki Retina Research Group, which evaluates the impact of intraocular lens (IOL) dioptric power on the cumulative incidence of posterior capsular opacification (PCO). The study aims to understand mechanisms of PCO and optimize IOL properties to minimize the incidence of PCO among cataract surgery patients. The research organization is the University of Helsinki.
Intraocular inflammation as a therapeutic target against late adverse effects in cataract surgery
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective registry study, which evaluates the impact of systemic medication (such as calcium channel blockers) on pseudophakic cystoid macular edema. The study aims to expand the understanding of the effects of prolonged intraocular inflammation and blood-ocular barrier disruption on cataract surgery long-term adverse events. The research organization is the University of Helsinki.
Association between periodontitis and blood-ocular barrier disruption among patients with wet age-related macular degeneration
Kymenlaakso Central Hospital and Mehiläinen Eye Hospital Ympyrätalo are participating in the Helsinki Retina Research Group’s prospective study, which evaluates the association between periodontitis and oral MMP-8 levels and aqueous flare levels among wet age-related macular degeneration (wAMD) patients. The study aims to expand the understanding of the risk factors for wAMD. The research organization is the University of Helsinki.
Effect of uneventful cataract surgery on wet age-related macular degeneration activity
Helsinki University Hospital Department of Ophthalmology is participating in the Helsinki Retina Research Group’s retrospective study, which aims to evaluate the effect of cataract surgery on wet age-related macular degeneration (wAMD) activity. The study aims to expand the understanding of the risk factors for wAMD and the optimal timing of cataract surgery among wAMD patients. The research organization is the University of Helsinki.
Association between Nd:YAG laser posterior capsulotomy and the risk of retinal detachment
Helsinki University Hospital Department of Ophthalmology is participating in the Helsinki Retina Research Group’s retrospective study, which aims to evaluate the association between Nd:YAG laser posterior capsulotomy and the risk of retinal detachment. The study aims to expand the understanding of the risk factors for retinal detachment and to optimize the follow-up after Nd:YAG laser posterior capsulotomy. The research organization is the University of Helsinki.
Effect of cataract surgery on quality-of-life among patients with severe bilateral wet age-related macular degeneration
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective study, which evaluates the effect of cataract surgery on patients with severe wet age-related macular degeneration in both eyes. The study aims to understand the impact of cataract surgery on quality of life in this patient group. The research organization is the University of Helsinki.
Effect of macular anatomical features as a prognostic factor for cataract surgery in patients with diabetes
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective study, which evaluates the impact of macular anatomical features as a prognostic factor for cataract surgery in patients with diabetes. The study aims to optimize cataract surgery and postoperative follow-up in patients with diabetes. The research organization is the University of Helsinki.
Clinical course of pseudophakic cystoid macular edema with nepafenac treatment
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective study, which evaluates the effect of nepafenac on the long-term prognosis of pseudophakic cystic macular edema. The study aims to optimize the treatment of this type of complication of cataract surgery. The research organization is the University of Helsinki.
The impact of intraocular lens selection in cataract surgery on the incidence and progression of wet age-related macular degeneration
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective registry study, which evaluates the impact of intraocular lens choice on the incidence and progression of wet age-related macular degeneration (wAMD). The study aims to expand the understanding of the effects of blue-light filtering on wAMD in patients who have undergone cataract surgery. The research organization is the University of Helsinki.
Effect of selective laser trabeculoplasty in exfoliative glaucoma eyes with prior argon laser trabebuloplasty
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s prospective study, which evaluates the effect of selective laser trabeculoplasty (SLT) in exfoliative glaucoma eyes with prior argon laser trabebuloplasty. The study aims to gain insight into the effect of SLT in this group of patients. The research organization is the University of Helsinki.
Effect of preoperative anti-inflammatory medication on cataract surgery outcomes in patients with diabetes
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s prospective study, which evaluates the effect of preoperative anti-inflammatory steroid and NSAID combination therapy on post-cataract surgery recovery in patients with diabetes. The study aims to optimize drug therapy for cataract surgery in patients with diabetes. The research organization is the University of Helsinki.
Incidence of pseudophakic cystoid macular edema in eyes with pupil expansion device
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective registry study, which evaluates the impact of pupil expansion device use on pseudophakic cystoid macular edema. The study aims to expand the understanding of the effects of blood-ocular barrier disruption and the mechanisms of cataract surgery long-term adverse events. The research organization is the University of Helsinki.
Anatomical and functional response to aflibercept in bevacizumab treatment-resistant wet age-related macular degeneration
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective registry study, which evaluates the anatomical and functional response to aflibercept in bevacizumab treatment-resistant wet age-related macular degeneration (wAMD). The study aims to optimize the medical treatment of wAMD. The research organization is the University of Helsinki.
Association between aqueous flare levels and retinal disease activity after anti-VEGF injections
Kymenlaakso Central Hospital is participating in the Helsinki Retina Research Group’s retrospective registry study, which evaluates the relationship between the aqueous flare levels and the activity of retinal diseases (wet age-related macular degeneration, diabetic macular edema, central retinal vein occlusion, pseudophakic cystic macular edema, myopic choroidal neovascularization) in patients treated with anti-VEGF. The study aims to optimize the anti-VEGF treatment and monitoring of retinal diseases. The research organization is the University of Helsinki.
SPECTRUM post-marketing trial, phase IV
Mehiläinen Eye Hospital Ympyrätalo is participating in a prospective follow-up study by Helsinki Retina Research Group and Bayer, which evaluates the efficacy and tolerability of Eylea (aflibercept) 8 mg anti-VEGF treatment in wet age-related macular degeneration (wAMD). The study aims to expand the understanding of efficacy and response to Eylea 8 mg to develop better treatment practices in the treatment of wAMD. The research organization is the Helsinki Retina Research Group.